High sensitive troponine T as a biomarker and determinant factor of myocardial dysfunction in sepsis

Methods We performed a prospective observational study with a cohort of 60 septic patients admitted to the ICU. Demographic data, severity scales, organ failure and doses of noradrenalin were registered. TnThs analysis was performed at baseline and in the first 24 hours a transthoracic echocardiography was performed to assess the ejection fraction (Simpson), once a correct resuscitation had been performed. Patients were monitored until hospital discharge. The statistical analysis was aimed to show whether biomarker TnThs acts as an early myocardial dysfunction biomarker in patients with sepsis and if it is an independent determinant factor of myocardial dysfunction. A bivariate analysis was performed using non-parametric tests and multiple logistic regression with the aim of obtaining a model adjusted to severity. Statistical significance if p < 0.05.